Heparan sulphate proteoglycans (HSPGs) including Glypicans are primarily involved in critical cellular pathways. Essentially, these groups of proteins are located on the cell membrane and modulate signalling pathways resulting in the cell growth process. Strikingly, the protein level of Glypican-1 (GPC-1) rises primarily during pancreatic cancer thus can be considered as a potential clinical biomarker. GPC-1 may also activate further downstream events, supporting the cancerous phase. To restrict the activity of GPC-1, several bio molecules can be deployed, of which the phytochemicals can be the best alternative. Molecular docking-based screening of a few phytochemicals revealed that the organosulfide class of phytochemicals effectively associate with the active site of the GPC-1 and hence harbours diagnostic and therapeutic potentials against pancreatic cancer.