Smoking has a negative impact on all systems of the human body and is a known risk factor for a variety of deadly illnesses. A range of pathophysiological processes, including vasomotor effects, irritation, smooth muscle development, and platelet dysfunction, mitigate the effects of smoking on the cardiovascular system (CVS). Furthermore, smoking affects a person’s oral microbiota and harms the periodontium via a variety of physical obstacles. The hypothalamic-pituitary-thyroid axis and thyroid function are both affected by smoking. Variations in thyroid hormone production, binding, transport, storage, and elimination, as well as changes in hormone concentration, are all negative mechanisms of smoking exposure. The goal of this study was to see how smoking affected the thyroid profile, serum TSH levels, T3 levels, and total T4 levels in smokers and non-smokers.

Thyroid profile highly significant variation (t3 and t4 decreased in smokers patient  0.79±0.40, 4.00±0.70 as compared to non smokers patient 1.51±0.38, 6.85±1.20) and serum TSH increased in smokers patient (7.70±1.60) as compared to non-smokers patient (P < 0.0001). serum Trop-I, ALT( SGPT) and AST( SGOT) concentration  increased in smokers patient (0.234±0.020, 75.30±5.43 and 34.40±2.20) as compared to non smokers patient (0.084±0.030, 40.90±8.90, 23.96±3.50) serum LDH and total CPK concentration also increased  in smokers  patient (185.90±4.20, 168.70±6.86) as compared to non smokers patient. To conclude, this research adds to our understanding of how smoking impacts thyroid functioning in cardiac biomarkers and adds to our understanding of its negative impacts. As a result, it might aid in the early detection and treatment of thyroid and cardiovascular illness among smokers.