Spread of the novel COVID-19 virus observed all across the globe. It is an international public health emergency as the cases have rised up to millions. On 11 March, WHO characterized COVID-19 as a global Pandemic. Even in India, there was outbreak of virus with alarming level of spread and severity. Air in the Earth’s atmosphere contains about 21% of oxygen which is enough for all living being to survive. Due to COVID-19 infection in lungs, oxygen saturation decreases causing HYPOXIA. If the patient does not show any sign and symptom of breathless and live normal life is called as happy hypoxia. There are many cases all over the world where patient suffers from happy hypoxia. In a survey, among 1712 patients with COVID-19 64.7% that is 1107 patients do not complain of shortness in breathe at time of admission. It is a dangerous threat to life if not intervene early. The correct line of treatment for both COVID-19 and happy hypoxia is very important. It helps in faster recovery of patient. Identifying comorbid condition and personal past history of patient, all the required blood investigation are to be done with HRCT scan. This helps an easy diagnosis and also reveals current health status. Oxygen saturation also plays main role in treatment part. The happy hypoxia state has worst effect in COVID-19 positive patients. If not taken seriously, this can lead to more oxygen deficiency. It is very difficult task to bring back the patient to normal natural oxygen, when once oxygen level is below 50%. Proper measures should be taken to avoid such complicated condition.