1Department of chemistry, School of Applied Sciences, Centurion University of Technology and Management, Odisha, India
2Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Odisha, India
Corresponding author email: srikanta.sahu@cutm.ac.in
Article Publishing History
Received: 13/10/2020
Accepted After Revision: 22/12/2020
Many of the Gram-negative bacteria are known from decades that cause life-threating diseases in human and many other animals. These bacteria have high tendency to survive in the host body rather quickly due to the presence of protective cell wall which defends from invasion of exogenous toxic agent. Therefore, developing new molecular scaffold with appropriate architectural unit that can circumvent the preventive cell wall of such bacteria is a huge challenge. We report herein, a synthetically simple and elegant, small organic molecule, PA-B-ester which endowed with unique molecular scaffold of prerequisite properties that can easily penetrate through the protective cell wall of the bacteria. We also successfully demonstrated antibacterial activity of PA-B-ester molecule against pathogenic gram-negative bacteria such as: Salmonella typhimurium and Escherichia coli.
Gram-negative bacteria, Salmonella typhimurium, Escherichia coli, infected diseases, antibacterial activity, small organic molecule, pathogenic bacteria,