Patients with sickle cell anaemia experience sickle cell crises throughout their life. Jaundice in a patient with sickle cell hemoglobinopathy is quite common and can be attributed to the sickle cell crisis, sickle cell hepatopathy, intrahepatic cholestasis or cholelithisis. In addition, occurrence of viral hepatitis is not uncommon in them and it is difficult to distinguish this aetiology clinically. In this study attempt has been made to identify the criteria to help differentiate amongst sicklers which patients should be investigated for viral hepatitis. Also, sicklers with hepatitis have been studied against non sicklers with hepatitis and also complications of hepatitis in these two groups.