COVID-19 or SARS CoV2 have caused a devastation situation in the world. People are dying at a rapid rate while scientists and researchers are facing problems in designing a virus against this disease. Many FDA approved drugs have been prescribed but they are not that effective. There is an urgent need for a vaccine with no side effects to cure this disease permanently. Nature had a hidden treasure of medicinal plants that can help the humans in eradicating this disease, one of them is Luteolin. It has shown anti-inflammatory, anti-cancer properties and have been previously used against other homologous strains of the virus existing previously. It is our hope to design a proper vaccine or drug against to overcome this pandemic situation. The current research is based on the in-silico studies of Luteolin and SARS CoV2 main protease to display potential of Luteolin as potential therapy against COVID-19. The results of present study form a basis of further experiments to examine Luteolin as antiviral compound.