The current pandemic of the Corona virus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has urged for the invention and implementation of effective drugs and vaccines to mitigate the adversity worldwide. Numerable studies are going on to identify and evaluate the efficacy of several synthetic drugs and vaccines. In this scenario, identification and use of plant-derived biomolecules against SARS-CoV-2 could be highly beneficial. Furthermore, upscale production of such plant metabolites and plant-based vaccines can help in controlling the pandemic. Several previous studies have reported the success of plant-based traditional medicines in immunity enhancement and decreasing viral loads. Thus, in depth researches involving the phytochemicals could reveal their roles and level of efficacy against SARS-CoV-2. Considering the present scenario, this review article presents the perspectives of using the phytochemicals in mitigating SARS-CoV-2, and the possible evolution of these phytochemicals into phytomedicines.