Fungal infection on nails is most underestimated by human beings due to lack of physical inconvenience apart from unconventional appearance of nail surface. Dermatophytes, yeasts and molds are major class of fungal pathogens responsible for nail infections, clinically called onychomycosis. These infections slowly progress into severe form deteriorating nail core by deposition of fungal spores which are unaffected by topical antifungal medicines. The disease takes a long time to heal by conventional procedure of topical treatments. The preset study explains onychomycosis from pathological perspective, reviewing the clinically relevant treatment strategies. Due to limitations in terms of antifungal drug penetration and patients’ hesitation towards laser therapies, the study provides an unexplored research horizon and need for developing device based strategies for treatment of onychomycosis.