Complex regional pain syndrome (CRPS) may develop subsequent to limb trauma and usually presents with sensory-motor and autonomic symptoms along with pain.Major CRPS symptoms include trauma-related cytokine release, exaggerated neurogenic inflammation, and neuroplasticity. The incidence of CRPS was estimated to be around 26.2 per 100,000 person years with male female ratio of 3.4. The highest incidence is reported in females aged 61–70 years. Patient with history of fall on right hand visited to private hospital. She had swelling for which plaster cast was applied for 7 days followed by permanent plaster cast applied for 21 days. After 21 days plaster cast was removed and patient was referred for physiotherapy. She complained of burning pain in the right hand for one and half months. X-ray confirmed fracture of distal end of radius. Features confirmed complex regional pain syndrome of the wrist. Specific treatment modalities included transcutaneous electrical nerve stimulation, progressive weight bearing, tactile desensitization, massage, and contrast baths. Patient recovered in 6 weeks therapy. Timely initiation of physical therapy is useful to reduce pain and swelling following fracture healing early recovery.