Pandemic of COVID-19 triggered by SARS-COV-2 now spread all over the world. Government and medical authorities are trying to manage this respiratory disease efficiently. Due to lack of essential supply, many sickbays are distress from paucity of sanitizing liquid, protecting masks as well asfree beds. For defeating this disease, it is necessary to come all countries togetherand coordinate with each other. Various challenges may come in the future, the major challenge may be the development of effective COVID-19 vaccine in order to deliversafeguardas well asinterfere the transmission of SARS-CoV-2 and the distribution of the vaccine. Internationally, it must be ensured thatthe vaccine should reach to every person. The manufacturing of the vaccine on mass scale is also a challenge. According to the population of the world, due to limited number of vaccine manufacturing companies, it will take so much time to manufacture the vaccine for reaching out to every person. The present paper mainly discussed about the upcoming challenges due to the COVID-19 pandemic that will face by the world in the future