Thyroid hormones, by their direct action on bone turnover, play a significant role in calcium and phosphorus homeostasis. Thyroid hormones have a vital role in calcium and phosphorus metabolism, which is frequently affected in thyroid disease. Increases in serum calcium and phosphorus levels should be monitored in thyroid illness. The goal of this research is to compare serum calcium and phosphorus levels in Sudanese hypothyroidism patients to those in seemingly healthy controls. A study of calcium, magnesium, and phosphorus in hypothyroidism patients was undertaken in the Vidharbha district. Between February 2019 and June 2020, a clinical-based case control study was performed. A research group of 100 hypothyroid patients from the Shalinitai Meghe Hospital in Nagpur was compared to a control group of 100 seemingly healthy people. Serum calcium, phosphorus, and magnesium levels were measured in blood samples obtained from the classes. In this sample, the results show that the test group had a significant decrease in mean serum calcium levels compared to the control group and a significant increase in mean serum phosphorus levels compared to the control group. Serum magnesium levels were considerably increased in comparison to controls, with mean values of the samples. In hypothyroid disorders, serum calcium and phosphorus levels are substantially altered. The levels of these minerals should be tested in hypothyroidism patients. Testing the levels of these minerals in SCH patients on a regular basis should be done. To avoid more bone complications, the primary cause should be treated and, if possible, mineral supplementation should be taken.