To develop the energy efficient protocol hybrid bio-inspired Ant-Cuckoo algorithm is proposed here to balance the energy consumption between the nodes evenly. The clusters are formed in the network using ACO algorithm. This is done based on the distance measurement among the nodes. Once the cluster is formed then the cluster head is selected upon the node energy value. Here flexible and rigid threshold is set for processing successive rounds of transmission with the same cluster head to avoid the frequent cluster reformation. Data routing using hauler nodes are selected with the assistance of cluster heads is done by using cuckoo search algorithm. Thereby efficient routes with reliable nodes are selected for data transmission. Simulation results are shown for proving efficiency for the proposed method.