Viral diseases are becoming deadlier day by day, Dengue is one the major re-emerging disease which affects not only rural but it affects a large population in urban areas too. This disease not only pose a threat to the developing countries, but also affects a large amount of people worldwide. This disease has become a major priority for the world health organisation. Every year a large amount of humans die due to unavailability of proper vaccine against this disease. Natural products have always played an important role in treating various viral and bacterial disease. Phyto-compounds are an approach to cure this disease and can help further to develop a vaccine against it. One of them is found in Boesenbergia Rotunda commonly known as Chinese ginger. One of major constituents of Chinese ginger is 4-hydroxypanduratin A. 4-hydroxypanduratin A has been used as neuro-protective, strong antioxidant, antibacterial and antifungal. In this research, in-silico studies has been performed to check whether 4-hydroxypanduratin A is a compound of interest or not.