School of Applied Sciences, Centurion University of Technology and Management, Odisha, India
Corrsponding author email: jyotiprakash.rath@cutm.ac.in
Article Publishing History
Received: 17/10/2020
Accepted After Revision: 25/12/2020
Tuberculosis continues to worry mankind. Because of the sharp increase in multi and total drug resistant cases the scientific community is looking for new drugs for Tuberculosis. The presence of Rhamnosyl residue in the cell wall of Mycobacterium tuberculosis pathogen and absence in human host projects the enzymes for its biosynthesis as possible drug targets. The presented work focuses on finding out possible plant based inhibitors for Rhamnose biosynthetic enzyme RmlC. 126 plant based anticancer compounds were obtained from NPACT database. The compounds were then evaluated for their binding affinity to RmlC through molecular docking procedure. 3-epi-betulinic acid acetate was found to be the best candidate inhibitor for RmlC and thus can work as a putative drug for Tuberculosis.
Docking, drug, NPACT, plant, Tuberculosis.