Bioscience Biotechnology Research Communications

An Open Access International Journal

P-ISSN: 0974-6455 E-ISSN: 2321-4007

Bioscience Biotechnology Research Communications

An Open Access International Journal

Ali Majid Al-Jibory1 ,Montaha A.Al-Saffar2 and Issam AL-Ani3

1,3Middle Technical university- College of Health and Medical Technologies- Baghdad-Iraq

2Middle Technical university ,Department of community health , Institute of Medical Technology ,Baghdad ,Iraq.

Corresponding author email: ali.majid1990.aa@gmail.com

Article Publishing History

Received: 15/05/2021

Accepted After Revision: 20/07/2021

ABSTRACT:

Autoimmune thyroid diseases is one of the most diseases which have an influence on the degree thyroid gland inflammation in patients that suffer from thyroid gland autoimmunity. one of diseasfeture is that lead to inflammotry cytokines, this study has been focused in this type of diseas which includeIFNγ and IL-17 as well as TSH and T3 hormones. Ninty (90) blood samples were collected from patients suffering thyroid gland disease in both gender whose age ranged 15-65 years ,for the period from September to the end of November 2021 from  Baghdad teaching  hospitals, samples divided into 60 patients groups  and 30 healthy control. All samples were tested to evaluate the levels of TSH and T3 hormones, IFNγ and IL-17A cytokines by using the ELISA technique. Patients groups were divided into autoimmune hyperthyroidism and autoimmune hypothyroidism, and the highest frequency was in age range (15-44) years at 76.00% and 63.16% respectively and thefemales frequency about 19 (76.00%) more than males 6 (24.00%) in autoimmune hyperthyroidism. Our results showed non-significant differences at the level of TSH and highly significant differences at the level of T3 hormones in autoimmune hyperthyroidism with a P-value ( p< 0.01), while the autoimmune hypothyroidism revealed opposite results. To search for potential immune markers for diagnosis assessment, our results indicate that the major mean value of immunological markers was IL-17  (75.08±42.19 ), followed by IFN-Gamma (49.69±21.47 ),while the less Mean value of immunological markers was in Anti –ds DNA , so the result revealed a strong correlation between the selected markers(IL-17), Our result leads to conclude that these markers are one of the main auto-inflammation cytokines in patients with autoimmune thyroiditis.So, the main objectives of this study are linked betweemimmunological indicatorssuch asIL-17A and IFN gamma and affective thyroiditis  , Patients with autoimmune thyroiditis have a substantial hormonal imbalance.

KEYWORDS:

TSH, T3, Ifnγ, IL-17A, Autoimmune Thyroiditis, Thyroid Inflammatory Cytokines

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