Bioscience Biotechnology Research Communications

An International  Peer Reviewed Refereed Open Access Journal

P-ISSN: 0974-6455 E-ISSN: 2321-4007

Bioscience Biotechnology Research Communications

An Open Access International Journal

Dibyashree Rout,1 Geetanjali Sahoo,1 Pratap K. Chhotaray,Harish C. Mohanta,2 and Srikanta Sahu1,

1Department of chemistry, School of Applied Sciences, Centurion University of Technology and Management, Odisha, India

2Department of Electronics and Communication Engineering, Centurion University of Technology and Management, Odisha, India

 Corresponding author email: srikanta.sahu@cutm.ac.in

DOI:

Article Publishing History

Received: 13/10/2020

Accepted After Revision: 22/11/2020

ABSTRACT:

Gram-negative bacteria are ubiquitous in nature. These bacteria are responsible for causing many noxious diseases such as: neurological abnormalities, gastroenteritis, and life-threatening Typhoid fever in human being and many other animals. Therefore, Salmonella has been a cause to longstanding worldwide health problem and became a reason for significant mortality globally. The toxicity nature of these bacteria is because of their high tendency to survive in the host body rather quickly due to the presence of protective cell wall which defends from invasion of exogenous toxic agent. Therefore, developing new organic small molecule with ideally disposed functional unit which can easily prevent the growth of bacteria is always demanding. We report herein, a synthetically simple and elegant, small organic molecule, PA-P-ester which having highly tunable prerequisite properties with respect to protective cell wall of the bacteria. The molecule, PA-P-ester shows high antibacterial activity against pathogenic gram-negative bacteria such as:  Salmonella typhimurium and Escherichia coli.

KEYWORDS:

Gram-negative bacteria, Salmonella typhimurium, Escherichia coli, infected diseases, antibacterial activity, small organic molecule, pathogenic bacteria

 

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