Bioscience Biotechnology Research Communications

An International  Peer Reviewed Refereed Open Access Journal

P-ISSN: 0974-6455 E-ISSN: 2321-4007

Bioscience Biotechnology Research Communications

An Open Access International Journal

Arya Dahane1, Ranjit S. Ambad2 and Swarupa Chakole1

1MBBS student atDatta Meghe Medical College, Wanadongri, Nagpur, India

2Department of Biochemistry Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur, India

3Department. of Community Medicine Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical
Sciences Sawangi (Meghe), Wardha

Corresponding author email: abad.sawan@gmail.com

Article Publishing History

Received: 24/03/2021

Accepted After Revision: 29/05/2021

ABSTRACT:

This article aims to discuss an autoimmune disorder of postsynaptic membrane where auto-antibodies are deposited at neuromuscular junction (NMJ) against ACh receptor (AChR) named MG.Discussing normal neuromuscular transmission .Alongwith (EAMG) Experimental autoimmune myasthenia gravis in which rabbits were immunised with AChR shows an allergic reaction to muscle AChR which usually occurs in MG patients. Furthermore, prognosis of specific antibodies namely AChR-Ab, MuSK-Ab, LRP4-Ab is discuss with clinically recommended tests. And ending with thymoma in MG patients and discussing necessity for thymus imaging of MG patients.

KEYWORDS:

Myasthenia Gravis, Auto-Antibodies , Neuromuscular Junction, Experimental Autoimmune MG, AChR, MuSK, LRP4, Thymoma.

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