Bioscience Biotechnology Research Communications

An International  Peer Reviewed Refereed Open Access Journal

P-ISSN: 0974-6455 E-ISSN: 2321-4007

Bioscience Biotechnology Research Communications

An Open Access International Journal

Ritesh Kumar and Kapil Hazarika

Department of Pharmacology Shree Guru Gobind Singh Tricentary
University, Gurugram, Haryana, India

Corresponding author email: ritesh_fmhs@sgtuniversity.org

Article Publishing History

Received: 19/05/2021

Accepted After Revision: 29/07/2021

ABSTRACT:

Since ancient times, medicinal plants have been used in various traditional medicinal systems which makes it very important to evaluate the toxicity of such plants. The hepatotoxic Pyrrolizidine alkaloids (PAs) have been considered as an important therapeutic extract that can be obtained from the medicinal plant Ageratum conyzoides. In this regard butanolic extract of the flowers of this plant were evaluated for its toxicity on a panel of normal mouse and human liver cell lines. Firstly, the flowers were extracted in n-Butanol for 24 h and the extract was treated to the normal mouse liver cells; AML 12 cells andthe normal human liver cells THLE-3 cells in an amount dependent manner for 24 h. Both the normal liver cells showed a decrease in cell viability upon increase in the amount of the extract indicating that caution must be exercised while utilizing this plant for medicinal purposes.

KEYWORDS:

Ageratum Conyzoides, Butanolic Extract, Hepatoxicity, Normal Liver Cells, Poisonous Plants, Pyrrolizidine Alkaloids

Download this article as:

Copy the following to cite this article:


Copy the following to cite this URL: