Bioscience Biotechnology Research Communications

An Open Access International Journal

P-ISSN: 0974-6455 E-ISSN: 2321-4007

Bioscience Biotechnology Research Communications

An Open Access International Journal

Sunidhi1, Sidhant2, Bhawna Verma3, Megha Gakhar4, Ramta Devi5 and  Poonam Devi6

1,2,6 MPT(Orthopaedics), College of Physiotherapy, PGIMS, Rohtak, India

5MPT(Sports), College of Physiotherapy, PGIMS, Rohtak, India

3,4 Assistant professor, College of Physiotherapy, PGIMS, Rohtak, India

Corresponding author email:


Article Publishing History


Accepted After Revision:


Pain neuroscience education ( PNE) is a new concept which helps the patients to modulate their pain perception and  experiences. The concept has shown effectiveness, comparable to other pain-relieving modalities including manual therapies.The objective of  the current review  is to explore the mechanism on which pain neurosciences work and various methodologies to implement pain neuroscience education. The current literature of pain neurosciences education has ben  reviewed and the evidences synthesised to explore the above objectives. Pain neuroscience education takes into account the complexity of a pain experience and aids patients in redefining pain by educating them on the various neurophysiological, neurobiological, social, and physical factors that may be present in their particular pain experience. The main objective of PNE is to assist individuals in rethinking their chronic pain. The mechanism through which PNE works is reframing the way we think about pain.

It is important to accept that in chronic pain, pain is not a direct measure of tissue damage and more chronic the pain it becomes less reliable gauge for tissue damage. It is also important to note that pain is influences by physical, psychological and social factors According to research, pain neuroscience education is a successful therapy technique for a number of chronic pain subtypes, including whiplash-related pain, neck pain in teenagers, and pain from lumbar surgery, complicated regional pain syndrome, and low back pain. PNE has advantages for participants from early adolescence to old persons. Pain Neuroscience Education is an effective method of managing pain and may be used by the physiotherapist to manage the patients with musculoskeletal conditions Chronic musculoskeletal pain is very common complaint and research shows that pain neuroscience education is effective in pain management and physiotherapists should utilize the concept in patients as it improves patient engagement in health care.


Catastrophization, Chronic Musculoskeletal Pain, Pain Biology Education, Pain Neuroscience Education, Reconceptualization.

Download this article as:

Copy the following to cite this article:

Sunidhi, Sidhant S, Verma B, Gakhar M, Devi R, Devi P. Evidence of Pain Neuroscience Education on Musculoskeletal Disorders: An Updated Review. Biosc.Biotech.Res.Comm. 2023;16(1).

Copy the following to cite this URL:

Sunidhi, Sidhant S, Verma B, Gakhar M, Devi R, Devi P. Evidence of Pain Neuroscience Education on Musculoskeletal
Disorders: An Updated Review. Biosc.Biotech.Res.Comm. 2023;16(1). Available from: <a href=”“></a>


The first mention of pain neuroscience education (PNE) in literature was in 2002 in patients with low back pain. (Meeus 2010). The terms pain biology education (PBE) as well as pain neurophysiology education have been used interchangeably with pain neuroscience education in literature, ( Meeus 2010 and  King 2016). Chronic pain is different from acute pain in its physiology and biopsychosocial impacts. Empowering the patients with knowledge regarding chronic pain mechanisms and neurophysiology alters patient’s fundamental perception regarding chronic pain, (Butler 2003, Eneberg-Boldon 2020 Alfaifi and Webb 2021). Goudman (2019)  state that  pain is a commonly used term for PNE and the textbook with same title serves as foundation for PNE.

The goal of PNE is to educate patients on the principles of neurophysiology of pain, nervous system sensitization, spinal inhibitory mechanisms, nervous system plasticity, and psychosocial factors that affect the experience of persistent pain,  (Louw 2016, Meeus 2010, Mosely 2002 & King 2016). The key underlying mechanism through with PNE is thought to function is re-conceptualization, which is described as the development of a new, less dangerous understanding of the nature of one’s pain. In cases of chronic pain, it is important to realise that pain is not proportional to tissue injury. Chronic pain is greatly influenced by psychological and social factors, (Moseley 2007).

PNE as a technique is administered by qualified healthcare professionals. It can be carried out separately or in groups. The neurophysiological concepts of chronic pain are explained to patients in simple language with the use of appealing and interesting freehand illustrations and metaphors. As a treatment PNE can be used alone but most frequently it serve as a foundation for comprehensive pain treatment strategy. Emerging research supports that PNE may be helpful for pain and function in the physical, psychological, and social realms, (Ryan 2010, (Moseley 2007, Moseley 2015, Moseley 2004, Louw 2011). The concept of PNE has gained importance in chronic musculoskeletal pain management. Recent years have seen an urge in literature regarding PNE. The present review was aimed to explore the methodologies through which PNE is implemented and the evidences for its effectiveness.


An electronic search was performed covering the last 2 decades (2003 –2022). The main search items were neuroscience, neurobiology, neurophysiology, pain, pain education, pain science, education, musculoskeletal disorders. All of the identified literature was reviewed for titles and abstracts. The selected studies on musculoskeletal pain were reviewed.

Table 1 lists the reviewed studies.

Table 1. Research studies on PNE in musculoskeletal disorders

Sr. No Author, year Study design Patient Population PNE Methodology Results
1 Meeus (2010) RCT Chronic fatigue syndrome 30-minute lecture on pain physiology Pain physiology education can be a significant therapeutic strategy in the treatment of individuals with chronic fatigue syndrome and chronic pain.
2 Louw  (2011) Systemic review Chronic musculoskeletal pain Studies on PNE published in English language from 1999-2010 Provide strong support for the idea that both passive and active physical movements are impacted by NE.
3 Kinga  (2016) Qualitative study Chronic musculoskeletal pain 3 Weeks pain neuroscience education Support the idea of reconceptualization is a key process and offer practical guidance for the work required to further explore this.
4 Shepherd  (2018) A Case Report Complex Regional Pain Syndrome (CRPS) A total of 26 sessions on pain neuroscience education (PNE), laterality training, motor imagery, and mirror training were conducted over a nine-month period. Long-term outcomes showed little to no fear-avoidance and catastrophizing behaviours, as well as no functional restrictions related to her foot or ankle.
5 Goudman (2019) A Clinical perspective Patients Undergoing Surgery for Lumbar Radiculopathy Before and after the surgery, 2 personally customised PNE sessions (each lasting about an hour), in addition to an educational brochure. Physical therapists can use the clinical perspective to help them implement perioperative PNE to patients having surgery for lumbar radiculopathy.
6 Watson  (2019) A mixed-methods systematic review and meta-analysis Chronic musculoskeletal pain Four qualitative studies (n = 50) examining patients’ experiences with PNE were included together with 12 randomised controlled trials (n = 755) reporting pain, disability, and psychosocial effects. Data from 12 RCTs showed that PNE can, in the short- to medium-term, improve pain, disability, pain catastrophizing, and kinesiophobia. Data from four qualitative investigations revealed a number of crucial factors that can improve patients’ experiences with PNE, such as letting patients share their own stories.
7 Corissa  (2021) Pre and post survey Chronic pain 9 out of the 26 participants who successfully completed both the before- and after-PNE questionnaires were included in the quantitative survey results. 5 responses only were gathered for the qualitative data. In comparison to pre-PNE scores, post-PNE scores demonstrated a statistically significant (p = 0.02) improvement. The qualitative aspect of this investigation showed that participants did indeed redefine pain.
8 Oosterwijck (2011) A pilot study Chronic whiplash associated disorders A 30 minutes 2 education session on PNE in 2 groups is given Data from chronic whiplash-related illnesses indicate that learning about pain physiology is associated with improvements in pain cognitions, pain thresholds, and pain-free movement performance.
9 Moseley  (2003) A randomized comparative trial Chronic low back pain Group education (GE) featured a single 4-hour education session with a group of 7–10 patients, while individual education (IE) involved four 1-hour teaching sessions. The findings showed that an intervention based on a cognition-specific motor control training method combined with pain physiology education is efficient in reducing pain and impairment related to chronic LBP.
10 Alfaifi and Webb (2021) A Case Study Chronic plantar fasciitis pain PNE was applied for 5 to 15 minutes of treatment with 4 other interventions.1st was Extracorporeal Shock Wave Therapy and 2nd was the mobilization grade III and VI were used for 5 minutes every session and 3rd was Low dye taping and 4th was stretching exercises for the lower limbs The symptoms in this case were not entirely resolved, the patient did report improvements in their symptoms and functional abilities, which gives hope that this case may be a useful addition to future therapies.
11 Nito (2018) Qualitative study followed a quantitative, randomized, and controlled trial Chronic idiopathic neck pain 43 students in one high school’s 10th to 12th grades were involved; 21 were in the experimental group and received pain neuroscience instruction along with neck and shoulder endurance exercises, whereas 22 were in the control group and did not get any intervention. Adolescents with chronic idiopathic neck pain approve the intervention, which consists of education about pain neurology and exercise, and they find it relevant and suitable.


Strong evidences in support of pain neuroscience education are coming up. Patients with pain are often interested in knowing what causes their pain. The biomedical education commonly uses ergonomics including anatomy, biomechanics and pathoanatomy overlooks the complex issues like central sensitization, peripheral sensitization, inhibition and neuroplasticity. Sometimes these are taken up by patients negatively and develop into fear avoidance and catastrophization. PNE embraces a biopsychosocial approach. One of the important aspects to note in PNE is pain experience. The review suggests that patients treated with PNE have less fear avoidance and catastrophizing behaviour.

PNE, by its definition, is an educational intervention aiming to alter a patient’s beliefs and cognitions regarding their pain experience, (Louw 2017).The education of pain neurophysiology goes hand in hand with de-education the common myths about the condition. PNE is usually delivered through lectures and interactive sessions. It includes pictures, stories, examples and metaphors to promote a positive and deep learning.

In order to implement the PNE it becomes essential to identify various biopsychosocial factors in patients with chronic pain. Hence, somatic, cognitive, emotional, behavioural, social and motivational factors must be included in pain assessment, (Amarins 2016). This may help to identify the dominant pain mechanism (nociceptive, neuropathic and central sensitization pain.

The mechanism through which PNE works is reframing the way we think about pain. It is important to accept that in chronic pain, pain is not a direct measure of tissue damage and more chronic the pain it becomes less reliable gauge for tissue damage. It is also important to note that pain is influences by physical, psychological and social factors. The coping and belief of patient improves due to reconceptualization of pain. This restores balance in pain mechanism and pain inhibition improves which ultimately improves health status and functioning.

The review shows level A evidence for the effectiveness of PNE in chronic musculoskeletal pain as supported by RCTs and meta-analysis. However, clinicians must consider proper assessment of pain experiences. The patients who have poor current concepts will improve with reconceptualization. Imparting PNE in language and method understandable to patient is the key to its effectiveness.


 Pain Neuroscience Education is an effective method of managing pain and may be used by the physiotherapist to manage the patients with musculoskeletal conditions.Chronic musculoskeletal pain is a relatively frequent complaint, and studies have shown that education in pain neurology is useful in treating it. Physiotherapists should use this idea with patients since it increases patient involvement in their care.


Alfaifi, Y. and Webb, D., 2021. The Effects of Pain Neuroscience Education with Conventional Physical Therapy on Chronic Plantar Fasciitis: A Case Study. Open Journal of Therapy and Rehabilitation, 9(2), pp.57-69.

Butler, D.S. and Moseley, G.L., 2013. Explain Pain 2nd Edn. Noigroup publications.

Eneberg-Boldon, K., Schaack, B. and Joyce, K., 2020. Pain neuroscience education as the foundation of interdisciplinary pain treatment. Physical Medicine and Rehabilitation Clinics, 31(4), pp.541-551.

Goudman, L., Huysmans, E., Ickmans, K., Nijs, J., Moens, M., Putman, K., Buyl, R., Louw, A., Logghe, T. and Coppieters, I., 2019. A modern pain neuroscience approach in patients undergoing surgery for lumbar radiculopathy: a clinical perspective. Physical therapy, 99(7), pp.933-945.

King, R., Robinson, V., Ryan, C.G. and Martin, D.J., 2016. An exploration of the extent and nature of reconceptualisation of pain following pain neurophysiology education: A qualitative study of experiences of people with chronic musculoskeletal pain. Patient Education and Counseling, 99(8), pp.1389-1393.

Louw, A., Diener, I., Butler, D.S. and Puentedura, E.J., 2011. The effect of neuroscience education on pain, disability, anxiety, and stress in chronic musculoskeletal pain. Archives of physical medicine and rehabilitation, 92(12), pp.2041-2056.

Louw, A., Nijs, J. and Puentedura, E.J., 2017. A clinical perspective on a pain neuroscience education approach to manual therapy. Journal of Manual & Manipulative Therapy, 25(3), pp.160-168.

Louw, A., Zimney, K., Puentedura, E.J. and Diener, I., 2016. The efficacy of pain neuroscience education on musculoskeletal pain: a systematic review of the literature. Physiotherapy theory and practice, 32(5), pp.332-355.

Meeus, M., Nijs, J., Van Oosterwijck, J., Van Alsenoy, V. and Truijen, S., 2010. Pain physiology education improves pain beliefs in patients with chronic fatigue syndrome compared with pacing and self-management education: a double-blind randomized controlled trial. Archives of physical medicine and rehabilitation, 91(8), pp.1153-1159.

Moseley, G.L. and Butler, D.S., 2015. Fifteen years of explaining pain: the past, present, and future. The Journal of Pain, 16(9), pp.807-813.

Moseley, G.L., 2003. Joining forces–combining cognition-targeted motor control training with group or individual pain physiology education: a successful treatment for chronic low back pain. Journal of Manual & Manipulative Therapy, 11(2), pp.88-94.

Moseley, G.L., 2007. Reconceptualising pain according to modern pain science. Physical therapy reviews, 12(3), pp.169-178.

Moseley, G.L., Nicholas, M.K. and Hodges, P.W., 2004. A randomized controlled trial of intensive neurophysiology education in chronic low back pain. The Clinical journal of pain, 20(5), pp.324-330.

Moseley, L., 2002. Combined physiotherapy and education is efficacious for chronic low back pain. Australian journal of physiotherapy, 48(4), pp.297-302.

Neto, M., Andias, R. and Silva, A.G., 2018. Pain Neuroscience Education and Exercise for Neck Pain: A Focus Group Study on Adolescents’ Views. Pediatric Physical Therapy, 30(3), pp.196-201.

O’Connor, M., Sillevis, R. and Erickson, M.R., 2021. Pain neuroscience education delivered by a student physical therapist for a patient with persistent musculoskeletal pain. The American Journal of Case Reports, 22, pp.e932212-1.

Ryan, C.G., Gray, H.G., Newton, M. and Granat, M.H., 2010. Pain biology education and exercise classes compared to pain biology education alone for individuals with chronic low back pain: a pilot randomised controlled trial. Manual therapy, 15(4), pp.382-387.

Shepherd, M., Louw, A. and Podolak, J., 2020. The clinical application of pain neuroscience, graded motor imagery, and graded activity with complex regional pain syndrome—A case report. Physiotherapy Theory and Practice, 36(9), pp.1043-1055.

Sutton, C.A., 2021. Pain Neuroscience Education as an Intervention for Chronic Pain.

Van Oosterwijck, J., Nijs, J., Meeus, M., Truijen, S., Craps, J., Van den Keybus, N. and Paul, L., 2011. Pain neurophysiology education improves cognitions, pain thresholds and movement performance in people with chronic whiplash: a pilot study. Journal of rehabilitation research and development, 48(1), pp.43-58.

Watson, J.A., Ryan, C.G., Cooper, L., Ellington, D., Whittle, R., Lavender, M., Dixon, J., Atkinson, G., Cooper, K. and Martin, D.J., 2019. Pain neuroscience education for adults with chronic musculoskeletal pain: a mixed-methods systematic review and meta-analysis. The journal of pain, 20(10), pp.1140-e1.

Wijma, A.J., van Wilgen, C.P., Meeus, M. and Nijs, J., 2016. Clinical biopsychosocial physiotherapy assessment of patients with chronic pain: The first step in pain neuroscience education. Physiotherapy theory and practice, 32(5), pp.368-384.

Zimney, K.J., Louw, A., Cox, T., Puentedura, E.J. and Diener, I., 2019. Pain neuroscience education: Which pain neuroscience education metaphor worked best?. South African Journal of Physiotherapy, 75(1), pp.1-7.