The first case of COVID-19 in China was identified on December 1, 2019. It was reported to WHO on December 31, 2019. Now COVID-19 has turned into one of the greatest health disasters and is declared as a pandemic and a global threat by World Health Organization on January 30, 2020. COVID-19 was declared as global pandemic on March 11, 2020. COVID-19 is a pathogenic viral infection which easily transmits through respiratory droplets and transmitted through their contact instead of air transmission. It is considered most contagious when people are symptomatic, although transmission is possible before symptom. With the increase in number of cases of infected patients and rise in mortality rates, there weren’t any definitive curative or preventive guidelines for physician to challenge this virus. Use of antiviral, immunotherapies, vaccines and other effective therapies are being investigated in different stages for evaluation of COVID-19. Trials of a number of drugs including remdesvir, ivermectin, hydoxychloroquine, chloroquine, favipiravir, merimepodib and lopinavir were reported. This review attempted to compile the outcomes and future research needs of these trials.