Bioscience Biotechnology Research Communications

An Open Access International Journal

P-ISSN: 0974-6455 E-ISSN: 2321-4007

Bioscience Biotechnology Research Communications

An Open Access International Journal

Ritesh Kumar and Kapil Hazarika

Shree Guru Gobind Singh Tricentary University, Gurugram, Haryana, India

Corresponding author email: ritesh_fmhs@sgtuniversity.org

Article Publishing History

Received: 09/05/2021

Accepted After Revision: 15/07/2021

ABSTRACT:

In December 2019, COVID-19 emerged as a pandemic which was identified as Severe Acute Respiratory Syndrome Corona Virus (SARS COV2). World Health Organisation (WHO) confirmed it as Global health crisiswhich affected lifestyle and economy of many countries. The evolution of pathogen virus causes changes in amino acid sequences which has posed difficultiesin developing a vaccine against this disease. The present study is based on evaluation of natural therapeutics for treatment of Covid-19.  Ginger which has main constituent as 6-gingerol,has been used to treat many respiratory disorders. In this study, In-silico studies were performed using autodock4 to study the interaction between 6-gingerol and S-Protein or Spike protein of SARS CoV2. The results indicate that Phytocompound 6-gingerol exhibited good binding energies ranging from -0.99 kcal/mol to -3.25 kcal/mol with the S-protein. This research suggests that 6-gingerol can be a potent anti-viral phytocompound to develop a vaccine against corona virus.The study provides a natural copound as Covid-19 treatment, which could be further studied by in-vitro and clinical research methods.

KEYWORDS:

Angiotensin Converting Enzyme 2(ACE2), COVID-19, Spike Protein, SARS CoV2, ,Zingiberofficinale

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