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Samira Shahsiah et al.
BIOSCIENCE BIOTECHNOLOGY RESEARCH COMMUNICATIONS EVALUATION OF TISSUE DISSOLUTION ABILITY OF MODIFIED CHLORHEXIDINE 47
of root canal system. There is no single solution that can
do all these (Rossi-Fedele, et al, 2012).
Our ai mis quantitative comparaison of tissue solu-
biity of NaOCl solutions and converted chlorhexidine.
Solution under-study in This resarci inclue NaOCl 25/5%,
NaOCl 5/2%, CHX2/0%, CHX+BKCandCHX+SLS. sodium
hypochlorite is mostly used in root treatment however
toxicityof this material for pri apical tissues is remained
as a basic concern (Cobankara et al, 2010). Chlorhexidine
was selected due to anti-microbial properties, less toxic-
ity than NaOCl, biocompatibility, and its stability of the
experiment. But it is proved that (Arcangelo, 2007) this
material has no acceptable capacity in high densities for
solving organic tissue so two type of surfactantswere
added ito CHX in order to increase solubility.
Results indicated that maximum solubility is related
to 5/25% sodium hypochlorite and average nega-
tive tissue solubility was related to normal saline.
After25/5%NaOCl, CHX+SLS had maximum tissue solu-
bility. Statistical analysis of ANOVA with 95% as con-
dence level was performed by 6 groups. And p<0/05
indicates that there is no signi ant différence (P=0/0).
In addition, in Hemogeneity of variances test (P<0.05),
variance of 6 group, has signi cant difference (P=0.011).
For comparing 6 group median, Welch test was used
in which signi cant difference was observed in groups
(P=0.0). for pairwise comparison of groups, Tamhane
was used. As there is no similar research in this case
we tested all solutions separately. In this study, average
solubility was related to NaOCl 25/5% and 5/2% which
was respectively 7/53% and 07/27% while there was no
signi cant difference in both group considering solubil-
ity (P=315). In addition, 25/5% NaOCl had maximum
tissue solubility. This case is compatible with Cobankara
et al (2010), Cbristensen et al (2008), Arcangelo et al
(2007), Naenni et al (2004), Okino et al (2004), Turkun
et al (1997), Hand et al (1998).
CONCLUSION
25/5% NaOCl had maximum tissue solubility. Other than
0/2% CHX and normal saline. Considering tissue solu-
bility, there is no signi cant difference in other solution
with NaOCl 25/5. Consequently, based on this research
using SLS 2% CHX+ 2/0% in canal washing can have
similar effect as NaOCl 25/5% regarding solubility.
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